Improving effect of enalapril maleate and folic acid tablets on heart function in patients with H-type hypertension and left ventricular hypertrophy
ZOU Qing
ZHAO Lian-you
LI Xue
XU Xi-ping
WANG Bin-yan
WEI Cong-ying
WANG Ji-peng
LU Xuan-hao
ZHANG Zhi-min
DING Lu
WANG Zeng-qiang
Abstract：Objective To observe the improving effect of enalapril maleate and folic acid tablets on heart function in patients with H-type hypertension and left ventricular hypertrophy (LVH).Methods The patients (n=160) were chosen and divided randomly into enalapril maleate group (EM group,n=80) and enalapril maleate and folic acid tablets group (EMFA group,n=80). After treatment for 12 m, the changes of blood pressure, heart function and level of plasma homocysteine (Hcy) were observed in 2 groups.Results ①SBP and DBP decreased significantly after treatment in 2 groups (P<0.01), and the comparisons in SBP or DBP had statistical differences between 2 groups after treatment (allP<0.05). Blood pressure decreased much significantly in EMFA group. ②After treatment, the level of plasma Hcy decreased significantly in EMFA group (P<0.01) and decreased in EM group (P<0.05), and the comparison in level of plasma Hcy had significantly statistical difference between 2 groups after treatment (P<0.01). The level of plasma Hcy decreased much significantly in EMFA group. ③The ratio of left ventricular peak early diastolic mitral flow velocity (E) and late peak flow velocity (A, E/A) and LVEF increased significantly in 2 groups after treatment (P<0.01). The comparisons in E/A and LVEF had statistical differences between 2 groups after treatment (P<0.05), which were more significant in EMFA group.Conclusion Enalapril maleate and folic acid tablets can reduce blood pressure and level of plasma Hcy and improve left ventricular diastolic and systolic functions in patients with H-type hypertension and LVH.
Keywords：Enalapril maleate and folic acid tabletsH-type hypertensionLeft ventricular hypertrophyHeart functionHomocysteine
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 188-191 )