Efficacy and safety of amiodarone in prevention atrial fibrillation after cardiac surgery：a Meta- analysis
HUANG Dan
HUANG He
WANG Zhi-qiang
HE Wang-wei
LIU Wan-li
MEI Yang
TONG Sui-yang
Abstract：Objective To review systematically the efficacy and safety of amiodarone in prevention of atrial fibrillation (AF) after cardiac surgery.Methods The databases of CBM (from 1978 to July, 2014), CNKI (from 1994 to July, 2014), VIP Database (from 1999 to July, 2014), WanFang Database (from 1990 to July, 2014), PubMed (from 1990 to July, 2014) and Cochrane Library (No. 7 of 2014 Vol.) were retrieved with computer, and data was screened and extracted by 2 independently researchers according to inclusion and exclusion criteria. After reviewing the quality by using modified JADAD scale, the included data was given a Meta-analysis by using RevMan 5.2 software. Results There were totally 18 documents included (all were randomized controlled trials) involving 1964 cases. The results of Meta-analysis showed that compared with placebo (control group), amiodarone (test group) decreased the incidence rate of AF after cardiac surgery (RR=1.46, 95%CI: 1.36~1.57,P<0.00001), while the comparison in safety between 2 groups showed no statistical difference (RR=1.16, 95%CI: 0.89~1.50,P=0.27). The subgroup analysis showed that different administration ways and different first medication time had no significant influence on efficacy of amiodarone (consistent with the overall efficacy).Conclusion Amiodarone can effectively reduce the incidence rate of AF after cardiac surgery compared with placebo, while there is no difference in safety between them.
Keywords：Atrial fibrillationAmiodaroneAfter cardiac surgery
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 165-169 )