Predictive value of plasma NT-proBNP to prognosis in elderly patients with acute decompensated systolic heart failure
MA Guo-dong
SHEN Ai-dong
Abstract：Objective To investigate the predictive value of plasma N-terminal pro brain natriuretic peptide (NT-proBNP) to prognosis in elderly patients with acute decompensated systolic heart failure (ADSHF). Methods ADSHF patients (n=128) were chosen and divided into 4 groups (Q1 group to Q4 group, each n=32). After followed up for 6 m and according to prognosis, the patients were divided into control group (n=70, non-readmission) and research group (n=58, readmission or death). The difference in left ventricular ejection fraction (LVEF), left ventricular fraction shortening (LVFS), left ventricular end-systolic volume index (LVESVI), 6-minute walk test (6MWT), readmission rate and mortality were compared among all groups. The best predictive value of NT-proBNP to prognosis was analyzed by using receiver operating curve (ROC). Results LVESVI, readmission rate and mortality were in a descending order from Q4 group, Q3 group to Q1 group (P<0.05), and LVEF, LVFS and 6MWT were in a descending order from Q1 group, Q2 group to Q4 group (P<0.05). After follow-up for 6 m, NT-proBNP and LVESVI increased significantly (P<0.05), and LVEF, LVFS and 6MWT decreased (P<0.05) in research group compared with control group. ROC analysis showed that area under curve (AUC) of short-term mortality predicted by NT-proBNP was 0.826. The mortality of patients with NT-proBNP≤205 ng/L was higher than those with NT-proBNP>205 ng/L. Conclusion NT-proBNP can independently review the severity and short-term prognosis in patients with ADSHF.
Keywords：N-terminal pro brain natriuretic peptideSystolic heart failureAcute decompensated periodeElderly patients
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 113-115 )