Establishment of rabbit model of exercise atrial fibrillation
YUAN Dou
TAN Chen
YAO Jian-min
LI Dan
HUANG Si-hui
XU Wei
Abstract：Objective To establish the animal model of exercise atrial fibrillation (AF) and review its results. Methods Healthy adult New Zealand rabbits (n=24) were divided into control group, mid-intensity group and high-intensity group (each n=8). The control group did not do any exercises and other groups did treadmill running with different intensity (for 1 h or one-time exhaustive exercise) for 5 d a week for 12 w. The size of atrium was detected by using echocardiogram before exercise and 8 w and 12 w after exercise. After exercise finished, Langendorff system is employed for isolated heart perfusion in all rabbits, and AF was induced by using S1S2 and induction rate of AF was recorded. Results Compared with control group, the left atrial anteroposterior diameter and right atrial anteroposterior diameter increased in mid-intensity group and high-intensity group after 8 w and after 12 w (all P<0.05). Compared with mid-intensity group, the left atrial anteroposterior diameter and right atrial anteroposterior diameter increased in high-intensity group after 8 w and after 12 w (all P<0.05). Compared with control group, the incidence of AF increased in mid-intensity group (45%vs. 60%) and high-intensity group (45%vs. 90%, all P<0.01). Conclusion Long-term and high-intensity treadmill running can enlarge atrial inner diameter and increase AF incidence in rabbits.
Keywords：RabbitsEndurance ExerciseAtrium dimensionAtrial Fibrillation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 94-96,99 )