Influences of pioglitazone on quantity of endothelial progenitor cells and adiponectin level in patients with unstable angina pectoris complicating diabetes
CHEN Li-dong
XIAO Min
ZHANG Xu-guo
ZHU Yan-xia
LIANG Peng-fei
ZOU Zhao-kun
Abstract：Objective To investigate the influences of pioglitazone on quantity of endothelial progenitor cells (EPCs) and adiponectin level in patients with unstable angina pectoris (UAP) complicating type 2 diabetes mellitus (T2DM). Methods The patients (n=57) were randomly divided into pioglitazone group (n=28) and control group (n=29), and pioglitazone group was treated with pioglitazone (30 mg/d) and control group was not given TZD drugs. The percentage of peripheral EPCs in karyocytes was detected by using flow cytometry and double color analysis before treatment and 12 w after treatment, and EPCs were localized with CD34+/KDR+double labeling. The changes of quantity of EPCs and level of serum adiponectin were compared between 2 groups before and after treatment. Results The quantity of EPCs had no statistical difference between 2 groups before treatment (P>0.05). After treatment for 12 w, the quantity of EPCs increased significantly in pioglitazone group (0.023±0.010 vs. 0.051 ±0.012, P<0.01), and had no statistical difference in control group (P>0.05). The quantity of EPCs was higher in pioglitazone group than that in control group 12 w after treatment (P<0.028). The level of serum adiponectin had statistical difference in pioglitazone group before and after treatment (P<0.05), while had no statistical difference in control group (P>0.05). The level of serum adiponectin was higher in pioglitazone group than that in control group 12 w after treatment (P<0.05). Conclusion Pioglitazone can improve the mobilization of EPCs and level of serum adiponectin in patients with UAP complicating T2DM.
Keywords：PioglitazoneEndothelial progenitor cellsCoronary atherosclerosisType 2 diabetes mellitus
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 69-71 )