Effect of Kangsite Cardioplegic Solution in myocardial protection during surgery in patients with severe valvular heart disease
LIU Lei
YAO Jian-min
ZHAO Xiang-dong
CUI Zhen-tian
LIU Jing
Abstract：Objective To compare the effects of Kangsite Cardioplegic Solution (histidine-triptophan-ketoglutalate solution, HTK Solution) and Lenghanxue Cardioplegic Solution in myocardial protection during surgery in patients with severe valvular heart disease. Methods The patients (n=46) undergone open-heart surgery supported by cardiopulmonary bypass (CPB) and without active rheumatism and coagulation disorders were chosen from Mar. 2012 to Mar. 2014. All patients were divided into observation group and control group (each n=23), and observation group was given HTK Solution and control group, Lenghanxue Cardioplegic Solution. CPB time, aorta cross-clamping time, auto-rebeat rate, incidence of post-surgery arrhythmia, dosage of vasoactive drug, duration of mechanical ventilation time and ICU monitoring time were recorded in 2 groups. The levels of creatine kinase MB (CK-MB) and serum cardiac troponin T (cTnT) were detected respectively at different time points (before surgery, and 4 h, 12 h and 24 h after surgery). Results The difference in CPB time, aorta cross-clamping time, incidence of post-surgery arrhythmia, duration of mechanical ventilation time and ICU monitoring time had no statistical significance between 2 groups during surgery (all P>0.05). Compared with control group, auto-rebeat rate increased (54.17%vs. 79.17%) and dosage of dopamine decreased after surgery for 24 h [(6.6±2.3)μg/(kg·min) vs. (5.2±2.1)μg/(kg·min), all P<0.05] in observation group. Compared with control group, the level of CK-MB decreased after 4 h [(49.7±11.8) IU/L vs. (24.5±2.0) IU/L], 12 h [(83.9±18.3) IU/L vs. (31.1±2.6) IU/L] and 24 h [(62.4±12.5) IU/L vs. (32.4 ±3.3) IU/L, all P<0.05] in observation group. Compared with control group, the level of cTnT decreased after surgery for 4 h [(1.20±0.13)μg/L vs. (0.21±0.04)μg/L], 12 h [(2.35 ±0.64)μg/L vs. (1.22±0.59)μg/L] and 24 h [(1.75 ±0.24)μg/L vs. (0.76±0.41)μg/L, all P<0.05] in observation group. Conclusion The protective effect of HTK Solution on heart function is better than that of Lenghanxue Cardioplegic Solution during surgery in patients with severe valvular heart disease.
Keywords：Severe valvular heart diseaseKangsite Cardioplegic SolutionLenghanxue Cardioplegic SolutionMyocardial protection
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 54-56 )