Relationship between reduction rate of N-terminal pro brain natriuretic peptide and prognosis in patients with acute myocardial infarction
MA Hong
WANG Li-qing
YOU Zhao-xiong
Abstract：Objective To discuss the relationship between reduction rate of N-terminal pro brain natriuretic peptide (NT-proBNP) and prognosis in patients with acute myocardial infarction (AMI). Methods AMI patients (n=100, male 61, female 39 and aged from 45 to 76) were chosen from Oct. 2012 to Oct. 2013. The level of plasma NT-proBNP was detected and reduction rate of NT-proBNP was calculated on the 7th d and 21st d after AMI attack, and then all patients were divided into group A (reduction rate>30%) and group B (reduction rate<30%). The incidence of major adverse cardiovascular events (MACE) was recorded from hospitalization time to 6 m later. The changes of left ventricular ejection fraction (LVEF) were detected respectively 1 w and 6 m after hospitalization. Results The difference in sex, age, smoking history, hypertension and hyperlipidemia had no statistical significance between 2 groups (all P>0.05). After 1 w, the difference in LVEF had no statistical significance between 2 groups (P>0.05). After 6 m, LVEF increased in group A compared with group B [(54.75±5.18)%vs. (34.65±8.11)%, P<0.05]. After following up for 6 m, the incidence of MACE was significantly lower in group A than that in group B (11%vs. 30%, P<0.05). Conclusion The level of NT-proBNP is correlated to prognosis in AMI patients. The prognosis is better and incidence of MACE is lower in patients with NT-proBNP reduction rate>30%than those in patients with NT-proBNP reduction rate<30%.
Keywords：Reduction rate of N-terminal pro brain natriuretic peptideAcute myocardial infarctionPrognosisCorrelation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 47-48,53 )