Correlation between G-238A polymorphism of tumor necrosis factor-α and coronary artery disease:a Meta-analysis
HUA Xian-ping
WANG Xian-ming
XIE Jian
CAO Chuan-bin
QIAN Jin
PENG Jun-qiu
ZHANG Zhen-jian
Abstract：Objective To investigate the correlation between G-238A polymorphism of tumor necrosis factor-α (TNF-α) and risk of coronary artery disease (CAD) by applying Meta-analysis. Methods The databases of PubMed, EMbase and CNKI were retrieved for collecting the case-control studies on correlation between G-238A polymorphism of TNF-α and CAD risk from database establishment time to May 13, 2014. After screening literature and extracting data by 2 independent researchers, the data was given a Meta-analysis by using Comprehensive Meta-Analysis software. Results There were finally 11 case-control studies included in 10 literature. The results of Meta-analysis showed that the correlation between G-238A polymorphism and CAD risk had no statistical significance [A vs. G:OR=1.08, 95%CI:0.89~1.30, I2=34.33%;AA vs. GG:OR=1.15, 95%CI: 0.59~2.25, I2=0%; GA vs. GG: OR=1.14, 95%CI: 0.88~1.48, I2=54.34%; AA vs. (GG+GA): OR=1.09, 95%CI:0.56~2.14, I2=0%;(GA+AA) vs. GG:OR=1.11, 95%CI:0.90~1.38, I2=41.92%]. The sensitivity analysis showed that all results were robust, and subgroup analysis had the similar results. No publication bias was detected. Conclusion G-238A polymorphism of TNF-αmaybe not correlated to CAD risk. It is suggested to conduct more higher-quality studies for further verification.
Keywords：Tumor necrosis factorPolymorphismCoronary artery diseaseCoronary heart diseaseMeta-analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 23-26 )