Preventive effect of warfarin on ischemia stroke in middle-aged and elderly patients with atrial fibrillation：a Meta-analysis
YANG Yu-fan
ZHU Wen-qing
CHENG Kuan
CHEN Qing-xing
XU Ye
Abstract：Objective To review the preventive effect of warfarin on ischemia stroke in middle-aged and elderly patients with atrial fibrillation (AF). Methods The Databases of Ovid, EMbase, Web of Science, China National Knowledge Infrastructure (CNKI), VIP Database and WanFang Database were retrieved with computer from Jan. 1, 2008 to Sept. 30, 2014 for collecting the randomized controlled trials (RCT) about the risk of ischemic stroke in middle-aged and elderly patients with AF treated with warfarin and aspirin. All literature was screened based on inclusion and exclusion criteria, and the included RCT were reviewed by using Cochrane risk bias tool. A Meta analysis was conducted by applying Stata12.0 software. Result There were totally 6 RCT included involving 15959 cases in warfarin group and 14528 in aspirin control group. The results of Meta-analysis showed that the risk of ischemia stroke is higher (by 2.8 times) in aspirin control group than that in warfarin group (OR=2.80, 95%CI:1.35-5.82). Conclusion The current evidence shows that warfarin can reduce the risk of ischemia stroke in middle-aged and elderly patients with AF.
Keywords：WarfarinaspirinAtrial fibrillationIschemia strokeMeta-analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 20-22 )