Deanxit combining doxepin for relieving anxiety and depression symptoms of cardiovascular diseases
ZHANG Er-jian
TIAN Fu-li
ZHANG Bin
Abstract：Objective To study the curative effect of deanxit combining doxepin on anxiety and depression symptoms in patients with cardiovascular diseases.Methods The patients (n=80) were chosen from Jan. 2013 to Mar. 2013 and divided randomly into control group and treatment group (eachn=40). The treatment group was given deanxit combining doxepin based on the routine therapy for cardiovascular diseases and control group was only given drugs for cardiovascular diseases and doxepin and/or benzodiazepine for 6 w. The curative effect and adverse reactions were reviewed, and Hamilton Depression Scale (HAMD) was used to detect patients before treatment and on the 6th w after treatment.Results Compared with control group, ineffective rate decreased (25.0%vs. 10.0%, P<0.05) in treatment group. The basic control rate was 20.0%, effectual rate was 27.5% and effective rate was 27.5% in control group, and 38.0%, 25% and 27% in treatment group. The scores of dyssomnia, retardation and hopelessness decreased in treatment group after treatment for 6 w (allP<0.05). Compared with control group the scores of dyssomnia, retardation and hopelessness decreased in treatment group (allP<0.05). In treatment group, there were 3 cases with dry mouth, 3 with fatigue, 3 with anorexia, 2 with abdominal distention and constipation, 2 with dizziness and 2 with tiredness.Conclusion Deanxit combining doxepin has definite curative effect on anxiety and depression symptoms of cardiovascular diseases, but safety is no ideal.
Keywords：Cardiovascular diseasesAnxiety and depression symptomsDeanxitDoxepinCombination therapyClinical study
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 758-759 )