Curative effect of nitroprusside injection through different administration routes on no-reflow during percutaneous coronary intervention in patients with acute coronary syndrome
LI Ze-ming
WU Long-fei
LIU Fu-rong
DENG Heng-ping
LI Lin
Abstract：Objective To compare the curative effect of intracoronary nitroprusside (NTP) injection through guiding catheter or micro-catheter on no-reflow (NR) during percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS).Methods The ACS patients with NR of target vessel during PCI were chosen (n=55, male 32 and female 23) from Jan. 2009 to Sept. 2013. All patients were divided into micro-catheter group (n=31) and guiding catheter group (n=24), and given intracoronary NTP injection (50 μg/time) during NR and given again every 2 min to 5 min until NR disappeared. The TIMI flow grading, TIMI flow frame count (TFC), adverse reaction incidence and mortality were compared in 2 groups before and after treatment.Results There were 29 cases (93.5%) in micro-catheter group and 19 (79.2%) in guiding catheter group with improved TIMI flow grading (P=0.22). After treatment, TFC decreased from (57.7±8.2) to (10.3±5.9) in micro-catheter group, and from (56.8±9.2) to (15.2±6.3) in guiding catheter group. The comparison between 2 groups before and after treatment had statistical difference (all P<0.01), and TFC was significantly higher in micro-catheter group than that in guiding catheter group after treatment (P<0.05). There were 2 cases (6.5%) in micro-catheter group and 5 (20.8%) in guiding catheter group died in hospital (P>0.05). There were 3 cases (9.7%) in micro-catheter group and 5 (20.8%) in guiding catheter group with temporary hypotension (P>0.05).Conclusion The curative effect of intracoronary NTP injection through micro-catheter is better than that through guiding catheter on NR during PCI in ACS patients.
Keywords：NitroprussideNo-reflowAcute coronary syndromePercutaneous coronary intervention
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 747-750 )