Hydroxysafflor yellow A for ameliorating injury of myocardial ischemia/reperfusion in SD rats
XU Ai-bin
LIU Jian-guo
ZHANG Jian
LI Jun-Xia
Abstract：Objective To study the effect of hydroxysafflor yellow A (HSYA) in ameliorating the injury of myocardial ischemia/reperfusion (MI/R) in rats.Methods The model of MI/R injury was established in SD rats through ligation of left anterior descending coronary arteries for 30 min and reperfusion for 3 h. All rats were divided into sham-operation group (Sham group), model group (MI/R group) and HSYA group (5 mg/kg, each n=30). The changes of myocardial infarction area, hematoxylin-eosin (HE) staining, electrocardiogram (ECG), myocardial injury markers and inflammatory cytokines (IL-1, IL-6 and TNF-α) were observed.Results The myocardial infarction area was significantly smaller in HSYA group than that in MI/R group (P<0.05). HE staining showed that myocardial cell morphology in HSYA group was similar to that in Sham group. The monitoring of hemodynamics and ECG showed that LVSP, +dp/dtmax, -dp/dtmax and heart rate (HR) were all higher in HSYA group than those in MI/R group (P<0.05). The levels of creatine kinase MB (CK-MB) and cardiac troponin I (cTnI) decreased in HSYA group compared with MI/R group (P<0.05), and levels of IL-1, IL-6 and TNF-α decreased too in HSYA group compared with MI/R group (P<0.05).Conclusion HSYA can reduce the severity and range of myocardial infarction, improve heart function, inhibit inflammatory cytokine release, and play a role of protecting and ameliorating myocardial ischemia.
Keywords：Hydroxysafflor yellow AMyocardial ischemia/reperfusion injuryRats
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 733-736 )