Curative effect of intensive atorvastatin therapy on no-reflow during percutaneous coronary intervention in elderly patients with acute myocardial infarction
WANG Yan-fei
CAO Xue-bin
JIA Xin-wei
XIE Jun-min
REN Yue
ZHAO Wen-ping
LI Xue-jiao
Abstract：Objective To observe the vascular endothelial protective effect and safety of intensive atorvastatin therapy in treatment of no-reflow (NR) during emergency percutaneous coronary intervention (PCI) in elderly patients with ST-segment elevation acute myocardial infarction (STEAMI).Methods The patients (n=48) were chosen from Dec. 2009 to Jan. 2013, and randomly divided into control group and treatment group (eachn=24). The treatment group was given atorvastatin (80 mg) and control group was given atorvastatin (20 mg) once a day for 10 d. The levels of blood fat, procollagen Ⅲ N-terminal peptide (PⅢNP), matrix metalloproteinase-9 (MMP-9) and von Willebrand factor (vWF), and adverse reactions were compared between 2 groups before and after treatment. Results The levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and vWF decreased in 2 groups after 10-d treatment (allP<0.05). After treatment and compared with control group, in treatment group the levels of LDL-C [(3.41±0.43) mmol/Lvs. (2.14±0.38) mmol/L], MMP-9 [(150.31±12.18) ng/mLvs. (115.41± 13.62) ng/mL] and vWF [(76.9±7.03)%vs. (48.31±6.9)%] decreased (allP<0.05), and PⅢNP [(114.71±13.23) ng/mLvs. (64.26±11.43) ng/mL] decreased (allP<0.05). The level of myocardial enzyme decreased in 2 groups than before (allP<0.05). There were 3 cases with symptoms of gastrointestinal disorders and there was no case with symptoms of abnormal distension and dyspepsia.Conclusion Intensive atorvastatin therapy can significantly ameliorate the levels of blood fat, PⅢNP, MMP-9 and vWF, protect vascular endothelium and inhibit inflammatory reaction in elderly patients with NR during emergency PCI.
Keywords：Acute myocardial infarctionElderly patientsAtorvastatinNo-reflowProcollagen Ⅲ N-terminal peptideMatrix metalloproteinase-9Von Willebrand factor
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 717-719 )