Correlation between platelet parameters and coronary lesion severity in patients with coronary heart disease
REN Jie
MA Bin
WANG Ming-xia
CHEN Tian-ping
QIU Guo-feng
Abstract：Objective To investigate the correlation between related platelet parameters and coronary lesion severity in patients with coronary heart disease (CHD).Methods The patients (n=198, male 128, female 70 and average age=64±11) with unstable angina pectoris (UAP) undergone coronary angiography (CAG) were analyzed retrospectively from Mar. 2013 to Sept. 2013. They were divided into control group (n=50), 1-vessel group (n=51), 2-vessel group (n=49) and multi-vessel group (n=48) according to the outcomes of CAG, and divided again into<20 group (n=55), 20~40 group (n=58) and >40 group (n=35) according to Gensini scores. The related platelet parameters, lesion number of coronary vessels and Gensini scores were detected in all patients.Results The difference in platelet count, P-LCR and thrombocytocrit had no statistical significance among 4 groups (allP>0.05). Compared with control group, in 1-vessel group, 2-vessel group and multi-vessel group platelet distribution width (PDW) showed an increasing trend, and mean platelet volume (MPV) decreased (allP<0.05). Compared with control group, in <20 group, 20~40 group and >40 group MPV and PDW increased (allP<0.05). MPV (RSD=0.211) and PDW were positively correlated to lesion number of coronary vessels (RSD=0.221, allP<0.05). PDW (RSD=0.239) and MPV (RSD=0.219) were positively correlated to Gensini scores (allP<0.05).Conclusion Combined detection of MPV and PDW has an important significance to judge the severity of coronary artery disease.
Keywords：Platelet distribution widthMean platelet volumeCoronary lesion severity
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 714-716 )