Influences of statins on pulse wave velocity and inflammatory factors in hypertensive patients
ZHAO Li-kun
WANG Zhao-xia
WANG Yu-xia
ZHANG Bao-zhong
Abstract：Objective To investigate the effect of anti-hypertension treatment combining statins in controlling the development of atherosclerosis in hypertensive patients.Methods The patients (n=405) were chosen according to inclusion criteria and then randomly divided into statins group and control group. The statins group was given rosuvastatin calcium (10 mg/d) and control group was only given anti-hypertension treatment. A study circle was 18 m. The changes of interleukin-6 (IL-6), matrix metalloproteinase-9 (MMP-9), and baseline detections of blood fat and pulse wave velocity (PWV) were recorded in 2 groups at time-points of 6 m, 12 m and 18 m. The changes of observation indexes and baseline values were compared and analyzed within or between 2 groups at different time-points.Results In statins group, the levels of triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), IL-6 and MMP-9 decreased, and level of high-density lipoprotein-cholesterol (HDL-C) increased compared with baseline values, and left baPWV decreased with statistical significance. In control group, the difference between all indexes and baseline values had no statistical significance. At time-points of 6 m, 12 m and 18 m, the levels of TG, CHOL, LDL-C, IL-6 and MMP-9 were lower, and HDL-C level was higher in statins group than those in control group with statistical significance.Conclusion Anti-hypertension treatment combining statins has effects of adjusting lipid, reducing MMP9 and IL-6, and improving arterial elasticity in hypertensive patients.
Keywords：Rosuvastatin calciumInterleukin-6Matrix metalloproteinase-9Pulse wave velocity
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 679-682 )