Preventive and therapeutic effects of ligustrazine on myocardial ischemia-reperfusion injury：a systematic review and Meta-analysis
WU Ping-yong
ZENG Xian-tao
WANG Xue-jun
ZHANG Chao
XIAO Min
CHEN Li-dong
ZHANG Xu-guo
Abstract：Objective To review systematically the preventive and therapeutic effects of ligustrazine on myocardial ischemia-reperfusion injury.Methods The databases of CBM, CNKI, VIP Database and Google Scholar were retrieved for collecting the randomized controlled trials (RCT) about the preventive and therapeutic effects of ligustrazine on myocardial ischemia-reperfusion injury from database establishment time to Jan. 2014. The data was screened according to inclusion and exclusion criteria, extracted and given quality reviewe by 2 researchers independently, and then given Meta-analysis by applying RevMan 5.2 software.Results There were totally 23 RCT included involving 1984 cases, and the results of Meta-analysis showed that the relieving rate of clinical symptoms was increased by 3.01 times in ligustrazine group than that in control group [OR=3.01, 95%CI=(2.35-3.86)]. In ligustrazine group, 5 RCT reported adverse events including mainly abdorminal distention, nausea and prolonged thrombin time, 12 RCT denied serious adverse events, and 6 RCT did not report drug adverse reactions.Conclusion Based on present evidence, ligustrazine has preventive and therapeutic effects on myocardial ischemia-reperfusion injury. As this analysis has limited quantity and quality, more large-sample RCT with higher quality are required for further identifying the results.
Keywords：LigustrazineMyocardial ischemia-reperfusion injurySystematic reviewMeta-analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 653-657 )