Correlation between homocysterine or B-type brain natriuretic peptide and left ventricular function in ;heart failure with preserved ejection fraction
HUANG Yong-xian
LI Xu-dong
GUO Jun-jin
WANG Wei
Abstract：Objective To investigate the correlation between homocysterine (Hcy) or B-type brain natriuretic peptide (BNP) and left ventricular function in patients with heart failure with preserved ejection fraction (HF-PEF). Methods The patients (n=97) with HF-PEF were chosen as HF-PEF group by using cluster sampling method, and then HF-PEF group was divided into 3 groups:grade II group (n=32), grade III group (n=37) and grade IV group (n=28). Meanwhile the persons having physical examination with normal heart function were chosen as control group (n=85). The levels of serum HCY and BNP were detected, the indexes of IVST, LVPWT, LVEDd, LVEF, E/A and E/E’ were detected by using ultrasonic cardiogram, and LVMI was calculated in 2 groups. Results Compared with control group, the level of HCY increased [(10.86±3.45)μmol/L vs. (32.84±8.51)μmol/L] and BNP increased [(200.55±100.30) pg/ml vs. (2310.52±235.50) pg/ml] in HF-PEF group (all P<0.01). Compared with grade II group, HCY, BNP and LVMI increased in grade III group and grade IV group (all P<0.01). HCY and BNP were positively correlated to each other (r=0.713, P<0.01). LVMI was positively correlated to BNP and HCY (r=0.675, r=0.634, all P<0.05). Conclusion The levels of serum BNP and HCY are positively correlated to left ventricular function in patients with HF-PEF. The combined detection of serum BNP has guiding significance in the diagnosis and anticipation of severity and prognosis of HF-PEF.
Keywords：Heart failurePreserved ejection fractionHomocysterineBrain natriuretic peptideLeft ventricular function
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 609-611 )