Influences of irbesartan hydrochlorothiazide on brachial endothelial function and carotid artery intima-media thickness
LU Hai-long
LI Lei
YANG Rong-li
LI Ping-jing
HAO Jing-bo
LI Dong-ye
Abstract：Objective To observe the influences of irbesartan hydrochlorothiazide on brachial artery endothelial function and carotid artery intima-media thickness (CA-IMT) in hypertensive patients. Methods The patients (n=137) with grade 1 or grade 2 hypertension were chosen from Jun. 2010 to Feb. 2013, among them 127 had completed this study and randomly divided into hydrochlorothiazide group (group 1, n=60) and irbesartan hydrochlorothiazide group (group 2, n=67). The patients in 2 groups were respectively given orally hydrochlorothiazide (25 mg) or irbesartan hydrochlorothiazide tablet (1 tablet) in every morning for 12 m. The changes of blood pressure (BP), blood fat, high-sensitivity C-reactive protein (hs-CRP), endothelium-dependent dilatation (EDD) and CA-IMT were detected before and after treatment. Results Compared with those before treatment and in 2 groups, systolic BP [(156.49±9.10) mmHg vs. (126.37±8.12) mmHg, (157.26±8.91) mmHg vs. (124.46±8.07) mmHg], and diastolic BP [(98.73± 5.54) mmHg vs. (77.65±5.42) mmHg, (99.54±5.38) mmHg vs. (76.36±5.71) mmHg] decreased after treatment (all P<0.01). EDD [(5.37±0.91)%vs. (6.79±1.08)%, P<0.01] increased and CA-IMT [(1.16±0.25) mm vs. (1.03±0.20) mm, P<0.05] decreased in group 2 compared with those before treatment. Compared with group 1, EDD [(5.56±0.99)%vs. (6.79±1.08)%, P<0.01] increased and CA-IMT [(1.15±0.19) mm vs. (1.03±0.20) mm, P<0.05] decreased in group 2 after treatment. Conclusion Irbesartan hydrochlorothiazide can improve brachial artery endothelial function and reduce CA-IMT at the same time of decreasing BP.
Keywords：Irbesartan hydrochlorothiazideHypertensionEndothelium-dependent dilatationIntima-media thickness
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 599-602 )