Curative effect of Danshen Chuanxiongqin Injection combining alprostadil on early renal damage in ;patients with hypertension
LIU Ze-jun
LI Wan-zhen
ZENG Yi-wen
LIU Wei
Abstract：Objective To investigate the curative effect of Danshen Chuanxiongqin Injection combining alprostadil on early renal damage in patients with primary hypertension. Methods The patients (n=120, male 62 and female 58, aged from 33 to 78) with mild or moderate primary hypertension and early renal damage were randomly divided into group A, group B and group C (each n=40). All patients were treated with valsartan, and group A was additionally given Danshen Chuanxiongqin Injection, group B, alprostadil injection and group C, Danshen Chuanxiongqin Injection and alprostadil injection for 2 w. The changes of blood glucose, blood fat,α1-microglobulin (α1MG) in serum,β2-microglobulin (β2MG) in serum and urine, vascular index and resistance index were detected before and after treatment. Results After treatment for 2 w,α1MG in serum andβ2MG in serum and urine decreased in 3 groups (all P<0.05). Compared with group A, serumα1MG [(21.3±3.97) mg/L vs. (16.7±3.49) mg/L], serumβ2MG [(3136.5±310)μg/L vs. (2557.6±275.8)μg/L] and urinaryβ2MG [(138.2± 13.8)μg/L vs. (109.7±13.6)μg/L, all P<0.01] all decreased in group C. Compared with group B, serumα1MG [(21.9±3.88) mg/L vs. (16.7±3.49) mg/L], serumβ2MG [(3188.6±298.7)μg/L vs. (2557.6±275.8)μg/L] and urinaryβ2MG [(139.3±14.2)μg/L vs. (109.7±13.6)μg/L, all P<0.01] all decreased in group C. Compared with group A, vascular index increased [(31.3±7.07) vs. (35.7±7.26)], and resistance index decreased [(0.60± 0.05) vs. (0.51±0.04), all P<0.05] in group C. Compared with group B, vascular index increased [(31.1±7.12) vs. (35.7±7.26)], and resistance index decreased [(0.61±0.05) vs. (0.51±0.04), all P<0.05] in group C. Conclusion Danshen Chuanxiongqin Injection and alprostadil all can relieve early renal damage in hypertensive patients, and combination of them will has better curative effect.
Keywords：Primary hypertensionEarly renal damageVascular indexResistance indexDanshen Chuanxiongqin InjectionAlprostadil
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 574-576 )