Correlation between homocysterine or macrophage migration inhibitory factor and carotid artery ;atherosclerosis
FU Bing
WANG San-min
TAN Yu
LI Min
GE Zhong-lin
LIU Jian-hua
CHEN Jie-chun
Abstract：Objective To discuss the relationship between homocysterine (Hcy) or macrophage migration inhibitory factor (MIF) and carotid artery atherosclerosis. Methods The patients (n=162) chosen from inpatient and outpatient departments were given detection of carotid artery intima-media thickness (CA-IMT) and plaque characters by using color Doppler ultrasonography, and then divided, according to ultrasonic outcomes, into normal group (n=32), thickening group (n=39) and plaque group (n=91). The levels of serum Hcy and MIF and related biochemical indexes were detected in all groups. The plaque group was further divided into stable subgroup (n=34) and unstable subgroup (n=57). The differences in levels of serum Hcy and MIF among 3 groups and between stable subgroup and unstable subgroup were compared, and correlation between Hcy or MIF and CA-IMT was analyzed. Results Compared with normal group, the levels of serum Hcy and MIF increased significantly in thickening group and plaque group (P<0.05), and higher in plaque group than those in thickening group (P<0.05). Compared with stable subgroup, the levels of serum Hcy and MIF increased significantly in unstable subgroup (P<0.05). Hcy and MIF were significantly correlated to CA-IMT (r=0.558, r=0.604, all P<0.05). Conclusion The levels of serum Hcy and MIF may related to the development of carotid artery atherosclerosis, and the increases of Hcy and MIF may induce unstable carotid plaque.
Keywords：Carotid artery atherosclerosisHomocysterineMacrophage migration inhibitory factor
Publication Date：2014-01-01
Pages：3( 565-567 )