Expressions of adiponectin and adiponectin receptor 1 and relationship between them and diabetic ;cardiomyopathy
SU Shi-yue
LI Jie-hua
ZONG Xiao-na
Abstract：Objective To discuss the effects of expressions of adiponectin and adiponectin receptor 1 (AdipoR1) in the development of cardiomyopathy through observing them in rats with T2DM. Methods The model of T2DM was established in rats, and the level of serum and myocardial APN was detected by using double-antibody sandwich ELISA, and expression of AdipoR1 protein was detected by using immunohistochemistry technique. Results Compared with control group, the level of serum and myocardial APN decreased, and expression of AdipoR1 protein decreased in T2DM group (P<0.05). The correlation analysis showed that serum APN was negatively correlated to serum insulin and HOMA-insulin resistance (HOMA-IR, r=-0.613, P<0.05;r=-0.637, P<0.05). The expression of AdipoR1 protein was positively correlated to myocardial APN (r=0.89, P<0.05), and negatively correlated to HOMA-IR and fasting insulin (r=-0.697, P<0.05; r=-0.593, P<0.05). Conclusion The level of serum and myocardial APN, and expression of AdipoR1 protein decrease in rats with diabetic cardiomyopathy. IR may play a role in the development of diabetic cardiomyopathy.
Keywords：Diabetic cardiomyopathyAdiponectinReceptorInsulin resistance
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 562-564,567 )