Level of Apelin-12 and correlation study in patients with coronary heart disease complicating diabetes ;mellitus
GAO Chao
LUO Chun-miao
FENG Jun
Abstract：Objective To analyze the level of Apelin-12 and correlation study in patients with coronary heart disease (CHD) in different lesion degrees complicating diabetes mellitus (DM). Methods The hospitalized patients (n=195, male 107 and female 88, aged from 34 to 87) examined with coronary angiography (CAG) were continuously chosen from Feb. 2011 to Feb. 2013, and then divided into 3 groups according to outcomes of CAG and complicating DM including normal group (n=59), CHD group (n=75) and CHD complicating diabetes group (CHD+DM group, n=61). According to the outcomes of CAG, the patients were divided into control group (n=53), 1-vessel group (n=58), 2-vessel group (n=36) and multi-vessel group (n=48). The outcomes of CAG were given Gensini scoring and level of serum Apelin-12 was detected. The correlation between Apelin-12 and CHD lesion degrees was analyzed. Results The level of serum Apelin-12 showed a decreasing trend in control group, 1-vessel group, 2-vessel group and multi-vessel group [(4.35±1.27) ng/mL vs. (3.36±0.84) ng/mL vs. (2.28±0.33) ng/mL vs. (1.69 ±0.48) ng/mL], and Gensini integral showed a increasing trend in different groups [(10.63±4.16) vs. (25.64± 8.53) vs. (47.18±16.32) vs. (65.18±18.43), all P<0.05]. The correlation analysis showed that Gensini integral was negatively correlated to the level of Apelin-12. Conclusion The level of Apelin-12 decreases in CHD patients, and its descending extent is correlated to coronary lesion degree.
Keywords：Coronary heart diseaseApelin-12Coronary angiographyGensini integral
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 548-550 )