Treatment of chronic heart failure with Western drugs combining Shengmai Injection：a systematic ;review on randomized controlled trials
YUAN Yang
MAO Jing-yuan
TANG E
HOU Ya-zhu
WANG Xian-liang
Abstract：Objective To review systematically the effectiveness and safety of Western drugs combining Shengmai Injection on chronic heart failure (CHF). Methods The databases of CNKI (from 1979-1 to 2013-12), VIP (from 1989-1 to 2013-12), WanFang Database (from 1978-1 to 2013-12) and Cochrane Library (4th issue of 2013) were retrieved with computer and related journals were retrieved manually for collecting the randomized controlled trials (RCT) about treatment of CHF with Western drugs combining Shengmai Injection. The quality of included RCT was assessed and effective data was extracted according to Cochrane Handbook, and all data was reviewed by using RevMan5.2.0 software. Results There were totally 12 RCT included involving 939 cases, and the quality of RCT all reached level C. The results of Meta-analysis showed that clinical effect of Chinese medicine [RR=1.23, 95%CI (1.141.33), P<0.01], heart function [RR=1.36, 95%CI (1.201.55), P<0.01] and integral of life quality scale [WMD=-6.49, 95%CI (-12.31-0.67), P=0.03] were improved, LVEF [WMD=9.22, 95%CI (5.8812.56), P<0.01] and 6MWT (P<0.05) increased, and BNP level decreased (P<0.05, P<0.01) in CHF patients. There was 1 RCT showed that Shengmai Injection might reduce the levels of SVR, vWF, P-selectin and D-dimer, and 2 RCT showed that Shengmai Injection might reduce NT-proBNP level and HRV. Conclusion Western drugs combining Shengmai Injection can further improve clinical efficacy in treatment of CHF.
Keywords：Shengmai InjectionHeart failureRandomized controlled trialsSystematic review
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 519-523 )