Correlation between L55M polymorphism of paraoxonase-1 and coronary heart disease in Chinese ;population：a Meta-analysis
HU Long-cai
ZHANG Wei
HU Hua-long
YANG Bo
Abstract：Objective To study the correlation between L55M polymorphism of paraoxonase-1 (PON1) and coronary heart disease (CHD) in Chinese population. Methods The original studies on the correlation between L55M polymorphism of PON1 and CHD were fully retrieved, eligible studies were included and data was merged. The data was analyzed taking odds ratio (OR) of different genetic models of PON1 and 95%CI as effective indexes. Results There were 6 original studies included into data merging involved 2338 cases (1229 with CHD and 1109 being health control). The results of Meta-analysis showed that the correlation between L55M polymorphism of PON1 and CHD susceptibility had no statistical significance [homozygote comparative model (MM vs. LL):OR=0.57, 95%CI:0.26-1.25, P=0.16, heterozygote comparative model (LM vs. LL):OR=1.46, 95%CI:0.79-2.71, P=0.22, dominant heredity model (MM+LM vs. LL):OR=1.32, 95%CI:0.73-2.38, P=0.35, and recessive heredity model (MM vs. LM+LL):OR=0.56, 95%CI:0.26-1.21, P=0.14]. Conclusion CHD susceptibility is not correlated to L55M polymorphism of PON1 in Chinese population.
Keywords：Chinese populationParaoxonase-1L55MPolymorphismCoronary heart diseaseMeta-analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 516-518 )