Correlation between genotypes and folic acid supplementation in patients with H-type hypertension
WANG Ting-ting
CHEN Jie
WU Di
GUO Rui-qi
Abstract：Objective To investigate the difference in blood pressure (BP) and level of plasma homocysteine (Hcy) in patients with H-type hypertension and different genotypes, and observe the changes of Hcy and BP after controlling BP and folic acid supplementation. Methods The patients (n=166) were chosen after diagnosed as H-type hypertension through Hcy detection. The level of plasma Hcy was detected before folic acid supplementation and data about past medical history and the highest historical BP level were collected. The patients were given MTHFR 677C/T genotyping and divided into groups according the results, including CC group (wild type), CT group (hybrid type) and TT (mutant type) group. All patients were given folic acid tables (0.8 mg/d) based on original BP control therapy, and after 3 m the levels of Hcy and BP were detected. Results ①The detective results of MTHFR 677C/T genotyping showed that there were 42 cases with CC type (25.3%), 42 cases with CT type (25.3%) and 82 cases with TT type (49.6%). ②Comparison in Hcy level before folic acid supplementation showed that Hcy level was higher in male cases than that in female ones (P<0.05), was higher in TT group than that in CC group and CT group (P<0.05), and had no statistical difference between CC group and CT group (P>0.05). ③Comparison in the highest historical BP level showed that systolic blood pressure (SBP) was higher in CC group than that in TT group (P<0.05), and had no statistical difference between CC group and CT group or between CT group and TT group (P>0.05), and diastolic blood pressure (DBP) had no statistical difference among 3 groups (P>0.05).④Comparison in Hcy level before and after folic acid supplementation showed that Hcy level decreased in 3 groups after folic acid supplementation (P<0.05). ⑤Comparison in difference of Hcy level before and after folic acid supplementation showed that Hcy level was higher in TT group than that in CC group and CT group (P<0.05), but there was no statistical difference between CC group and CT group. ⑥Comparison in difference of BP level before and after folic acid supplementation showed that SBP was higher in CC group than that in TT group (P<0.05), and there was no statistical difference between CC group and CT group or between CT group and TT group (P>0.05). There was no statistical difference in DBP among 3 groups (P>0.05). Conclusion There is difference between genotypes and Hcy level and the highest historical BP level in patients with H-type hypertension. Folic acid supplementation can effectively reduce Hcy level, and may have better effect on TT genotype of MTHFR 677C/T. Anti-hypertension drugs combining folic acid supplementation can more effectively reduce BP level in patients with H-type hypertension and CC genotype of MTHFR 677C/T.
Keywords：H-type hypertensionFolic acidMTHFRCurative effect
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 486-489 )