Predictive value of plasma BNP to atrial thrombosis in patients with CHD complicating atrial fibrillation

WANG Yang; MI Shu-hua; ZHOU Yun; YANG Hong-xia

doi:10.3969/j.1674-4055.2014.04.34

Abstract：Objective To analyze the predictive value of plasma B-type natriuretic peptide (BNP) to atrial thrombosis in patients with coronary heart disease (CHD) complicating atrial fibrillation (AF). Methods The patients (n=98) were divided, according to the occurrence of left atrial thrombus, into control group (n=52, without atrial thrombosis) and research group (n=46, with atrial thrombosis). The levels of BNP, glycated hemoglobin (HbAlc), total cholesterol (TC), oxidized low-density lipoprotein (ox-LDL), high-density lipoprotein-cholesterol (HDL-C), high-sensitivity C-reactive protein (hs-CRP), left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDd) and left atrial diameter (LAD) were detected and compared in 2 groups. The correlation between above indexes and left atrial thrombosis was analyzed by using multiple Logistic regression analysis. Results Compared with control group, in research group the levels of BNP [(358.6±77.8) pg/ml vs. (1102.9 ±315.7) pg/ml, P=0.001], hs-CRP [(5.8±1.0) mg/L vs. (7.4±1.3) mg/L, P=0.027], ox-LDL [(3.4±0.8) mmol/L vs. (4.0±0.9) mmol/L, P=0.038], LVEDd [(58.1±5.5) mm vs. (74.3±6.8) mm, P=0.030] and LAD [(32.5±3.8) mm vs. (39.6±4.3) mm, P=0.021] increased significantly, and LVEF [(57.3±3.8)%vs. (48.2±3.1)%, P=0.015] and HDL-C [(1.08±0.27) mmol/L vs. (0.72±0.16) mmol/L, P=0.029] decreased significantly. The levels of HbA1C and TC had no statistical difference between 2 groups (P>0.05). The multiple Logistic regression analysis showed that BNP (OR=1.986, P=0.009) and LAD (OR=0.863, P=0.028) were independent predictive factors of atrial thrombosis. Conclusion BNP can independently predict atrial thrombosis in patients with CHD complicating AF.