Curative effects of warfarin and aspirin in patients with severe heart failure complicating persistent atrial fibrillation
SU Zhuo-jie
HUANG Bao-rong
CHEN Wei-liang
Abstract：Objective To investigate the curative effects of warfarin and aspirin during anticoagulant treatment in patients with severe heart failure complicating persistent atrial fibrillation (AF). Methods The patients (n=89) were retrospectively chosen and divided, according to CHADS2 scoring, HAS-BLED scoring and different anticoagulant drug administrating, into research group (n=43) treated with warfarin and control group (n=46) treated with aspirin. The incidence rates of ischemia events (including ischemic stroke, transient cerebral ischemic attack and peripheral arterial embolism) and hemorrhagic events (including intracranial hemorrhage, gastrointestinal bleeding and urinary bleeding) were compared between 2 groups. Results The incidence rates of ischemic stroke, transient cerebral ischemic attack and peripheral arterial embolism decreased significantly in research group compared with control group (4.65% vs. 15.22%, 11.63% vs. 21.74% and 2.33% vs. 8.69%, all P<0.05). The incidence rates of intracranial hemorrhage, gastrointestinal bleeding and urinary bleeding were, respectively, 2.33%vs. 2.17%, 9.30%vs. 10.86%and 9.30%vs. 8.69%in research group and control group (P>0.05). After following up for 1 y, the sudden death rate was, respectively, 6.98%vs. 6.52%in research group and control group (P>0.05). Conclusion According to CHADS2 scoring and HAS-BLED scoring, warfarin can reduce the incidence of ischemia events and not increase that of hemorrhagic events in patients with severe heart failure complicating permanent AF.
Keywords：WarfarinAspirinHeart failureAtrial fibrillationPermanence
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 461-463 )