Correlation between metabolic disorders and vascular complications in patients with type 2 diabetes mellitus
ZHAO Chun-yan
Abstract：Objective To observe the occurrence of metabolic disorders in patients with type 2 diabetes mellitus (T2DM) and correlation between metabolic disorders and vascular complications. Methods According to the diagnostic standard of metabolic syndrome (2004) of the Chinese Diabetes Society (CDS) of Chinese Medical Association, all patients (n=230) were divided into T2DM group (n=60), group of T2DM complicating 1 metabolic disorder complication (MS1 group, n=97), group of T2DM complicating 2 metabolic disorder complications (MS2 group, n=50) and group of T2DM complicating 3 metabolic disorder complications (MS3 group, n=23). The clinical and biochemical indexes were compared, and incidence rates of carotid artery intima-media thickening (CA-IMT), diabetic retinopathy (DR) and diabetic nephropathy (DN) were observed in 4 groups. The relationship between vascular complications and complicating metabolic disorders were analyzed by using Logistic regression model. Results The patients in MS1 group accounted for 42.2%among all patients, those in MS2 group for 21.7%, and those in MS3 group for 10.0%. The levels of BMI, HOMA-IR, FBG, 2hPG, UA, TG and TC all increased significantly in MS1 group, MS2 group and MS3 group compared with T2DM group (P<0.05). The levels of BMI, SBP, DBP, FBG, 2hPG, UA, TG, TC and LDL-C increased and HDL-C level decreased in MS2 group compared with MS1 group (P<0.01), and the levels of BMI, SBP, DBP, HOMA-IR, FBG, 2hPG, UA and TG increased and HDL-C level decreased in MS3 group compared with MS1 group (P<0.01). The levels of SBP, DBP, FBG, 2hPG and UA increased in MS3 group compared with MS2 group (P<0.01). As metabolic disorders increased, the incidence rates of CA-IMT, DR and DN also increased (P<0.01). Dichotomy Logistic regression analysis, taking CA-IMT, DR, and DN as independent variables and BMI, SBP, DBP, FBG, 2hPG, TG and HDL-C as dependent variables, showed that SBP, DBP and 2hPG were independent risk factor of CA-IMT, DBP and TG were independent risk factor of DR, and SBP and TG were independent risk factor of DN. Conclusion T2DM complicating other metabolic disorders are correlated to occurrence of CA-IMT, DR and DN.
Keywords：Type 2 diabetes mellitusMetabolic syndromeComplications
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 444-447 )