Curative effect of allopurinol in patients with acute myocardial infarction complicating hyperuricemia
YIN Gang
XIA Qing
LI Yue-fan
Abstract：Objective To observe the curative effect of allopurinol in patients with acute myocardial infarction (AMI) complicating hyperuricemia. Methods The patients (n=75) were chosen from Nov. 2011 to Jun. 2013, and divided into control group (n=37) and treatment group (n=38) by using random number table. The control group was given anti-platelet, anti-thrombosis and lowing-lipid therapy, and treatment group was given allopurinol besides of the same therapy in control group. The changes of serum N-terminal pro brain natriuretic peptide (NT-proBNP) were detected, and 6-minute walk test (6MWT) was given to patients after diagnosis of AMI for 6 m. Results After treatment for 1 w, the level of NT-proBNP decreased significantly in control group and treatment group (all P<0.01). The level of NT-proBNP decreased in treatment group [(256±215) pg/mL] compared with control group [(396± 264) pg/mL, P<0.05] after treatment. 6MWT was (263±70) min in control group and (337±62) m in treatment group (P<0.01). Conclusion Allopurinol can reduce the level of NT-proBNP, increase 6MWT and improve heart function in patients with AMI complicating hyperuricemia.
Keywords：AllopurinolMyocardial infarctionHyperuricemiaB-type natriuretic peptide
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 436-437,441 )