Gender Differences in in-hospital mortality between male and female patients with ST-segment elevation myocardial infarction

FU Hao; HUA Qi; ZHAO Yu-sheng

doi:10.3969/j.1674-4055.2014.04.17

Abstract：Objective To study the difference in in-hospital mortality between male and female patients with ST-segment elevation myocardial infarction (STEMI). Methods The patients (n=1189) were chosen (including 869 male ones and 320 female ones, aged from 23 to 91) from Jan. 1, 1994 to Dec. 31, 2006. All patients were divided into group A (age<65, n=571), group B (aged from 65 to 74, n=419) and group C (age≥75岁, n=199). The clinical data of age, gender, type 2 diabetes mellitus (T2DM), blood fat and blood pressure (BP) were collected from the patients. Results In group A, in-hospital mortality increased in female patients compared with that in male ones (3.1%vs. 8.3%, P<0.05). In group B, in-hospital mortality increased in female patients compared with that in male ones (11.9%vs. 20.1%). In group C, the difference in in-hospital mortality had no statistical significance between male and female patients (P>0.05). In 3 groups, the odds ratio (OR) of in-hospital mortality in female patients showed a descending trend (2.861 vs. 1.875 vs. 1.143) as age increasing. Multivariate analysis showed that, after adjusting confounders, age (OR=1.154, 95%CI:1.052~1.264) and hypertension (OR=7.685, 95%CI:2.276~25.946) were independent risk factors of in-hospital mortality, and emergency reperfusion treatment (OR=7.685, 95%CI:0.007~0.098) was protective factor in group A. In group B, female (OR=1.875, 95%CI: 1.088~3.232) was an independent risk factor of in-hospital mortality. Conclusion In-hospital mortality is higher in female patients that that in male ones, while the difference will decrease as age increases. In patients aged<65, age and hypertension are risk factors of in-hospital mortality and emergency reperfusion treatment is protective factor. In Patients aged from 65 to 74, female is a risk factor of in-hospital mortality.