Comparison in effects of Qili Qiangxin Capsules and betaloc on heart function and BNP in rats with heart failure
BAI Ling
WANG Jun
LIU Ping
HAN Ke
MA Ai-qun
Abstract：Objective To compare the influences of Qili Qiangxin Capsules and betaloc on heart function, ventricular remodeling and brain natriuretic peptide (BNP) in rats with heart failure. Methods The rats with myocardial infarction complicating heart failure (n=44, raising for 4 w) were divided into model group, low-dose Qili Qiangxin Capsules group (low-dose group, 0.25 g/kg.d), high-dose Qili Qiangxin Capsules group (high-dose group, 1.0 g/kg.d), betaloc group (10 mg/kg.d) and sham-operation group. All groups were intragastrically given corresponding drugs once a day for 4 w. Heart rate (HR) was detected, and LVESD, LVEDD, LVEF and LVFS were detected by using echocardiogram. Heart mass index (HW/BW) was calculated and BNP level was detected by using enzyme-linked immunosorbent assay (ELISA). Results Compared with model group, LVESD and LVEDD decreased significantly and LVEF and LVFS increased in high-dose group and betaloc group (P<0.05). Compared with model group, HW/BW and BNP level decreased significantly in high-dose group (P<0.05). Conclusion Qili Qiangxin Capsules in high dose, as betaloc, can improve left ventricular function, and relieve significantly ventricular remodeling in rats with heart failure.
Keywords：Qili Qiangxin CapsulesHeart failureHeart functionBrain natriuretic peptideRats
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 408-410 )