Curative effects of ticagrelor and clopidogrel on acute coronary syndrome:a Meta-analysis
LIU Xiao-xiong
XIA Hao
ZHANG Yan
WAN Nian
LIU Wan-li
MEI Yang
TANG Dong-liang
LI Lei
Abstract：Objective To compare the curative effect and safety of ticagrelor and clopidogrel in treatment of acute coronary syndrome (ACS). Methods The databases of PubMed, CENTRAL and CNKI were retrieved with computer for collecting the RCT about comparison in curative effect and safety of ticagrelor and clopidogrel in treatment of ACS supplemented manually for searching reference from Jan. 2007 to Apr. 2014. After rigorous reviewing on quality, the data was extracted from eligible RCT and given a Meta-analysis by using RevMen5.1 software. Results There were totally 6 RCT included. The results of Meta-analysis showed that there was no statistical difference between ticagrelor and clopidogrel in the incidence of MACE (OR=0.67, 95%CI:0.40-1.11, P=0.12), myocardial infarction (OR=0.92, 95%CI: 0.81-1.04, P=0.17), stoke (OR=1.15, 95%CI: 0.89- 1.49, P=0.28) and bleeding (OR=1.05, 95%CI:0.96-1.15, P=0.31), but there was statistical difference in the incidence of dyspnea (OR=1.87, 95%CI:1.70-2.06, P<0.00001). Conclusion In ACS treatment, the incidence of dyspnea is higher when administrating ticagrelor, but incidence of MACE, myocardial infarction, stoke and bleeding were similar when administrating ticagrelor or clopidogrel. Clopidogrel may be substituted by ticagrelor, especially in the patients with clopidogrel intolerance or resistance.
Keywords：TicagrelorClopidogrelAcute coronary syndromeMeta-analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 396-399 )