Influence of bone marrow mononuclear stem cells transplantation on heart function after myocardial infarction:a Meta-analysis
CAO Teng
WANG Jia-ning
TANG Jun-ming
ZHANG Lei
LI Xiao-ling
YANG Jian-ye
ZHENG Fei
WANG Lu
Abstract：Objective To discuss the curative effect of bone marrow mononuclear stem cells (BMMSC) transplantation on myocardial infarction (MI). Methods The databases of PubMed, Cochrane, CNKI, WangFang Database and VIP Database were retrieved by using computer for collecting the randomized controlled trials (RCT) about the treatment of MI with BMMSC transplantation. The influence of BMMSC transplantation on heart function after MI was studied through a Meta-analysis on extracted data. Results A Meta-analysis was conducted in included 12 RCT and after followed up for 3 m, the comparison in all indexes and base values showed that LVEF increased significantly (WMD=3.65%, 95%CI:3.35%-3.95%, P<0.00001) but there was significant heterogeneity (I2=86%, P<0.00001) after BMMSC transplantation. The analysis in subgroups showed that in subgroup 1 (basic LVEF<40%) LVEF increased than that in control group (WMD=4.06%, 95%CI:3.74%-4.37%, P<0.00001), and in subgroup 2 (basic LVEF>40%) LVEF had no statistical difference compared with control group (WMD=-0.89%, 95%CI:-1.94%-0.15%, P>0.05). LVESV decreased in BMMSC group compared with control group (WMD=-6.28%, 95%CI: -8.39%--4.16%, P<0.00001). LVEDV had no statistical difference but had significant heterogeneity between BMMSC group and control group (P=0.0005, I2=70%). The analysis in subgroups showed that in subgroup 1, heterogeneity could not be removed (P<0.00001, I2=89%), and after excluding the trials with higher LVEDV, heterogeneity was removed and difference had statistical significance (WMD=-4.29%, 95%CI:-8.14%--0.45%, P<0.05), while in subgroup 2, the difference had no statistical significance compared with control group (WMD=-1.41%, 95%CI:-6.04%-3.22%, P>0.05). Conclusion BMMSC transplantation can improve left ventricular systolic function and inhibit ventricular remodeling after MI. It has significant efficacy in patients with basic LVEF<40%.
Keywords：Bone marrow mononuclear stem cellsCell transplantationMyocardial infarctionHeart functionMeta-analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 390-395 )