Influences of aerobics with different intensities on blood glucose and myocardial oxygen free radicals in diabetic rats
WANG Yu
YU Rui-xue
HU Si-bo
Abstract：Objective To investigate the influences of aerobics with different intensities on blood glucose and myocardial oxygen free radicals (OFR) in diabetic rats. Methods The rat model of diabetes was established by feeding high-fat diet and intraperitoneal injection of STZ, and then 40 rats were randomly divided into model group, low-intensity aerobics group, mid-intensity aerobics group and high-intensity aerobics group (each n=10). All aerobics groups underwent treadmill running, respectively, for 10 m/min (=30%VO2MAX), 15 m/min (=50%VO2MAX) and 20 m/min (=70%VO2MAX) 1h a day, 6 da week for 6w. The levels of fasting blood glucose (FBG), fasting insulin (FINS) and HOMA-IR in caudal vein, and superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) and nitric oxide synthase (NOS) in myocardial tissue were detected. Results After injecting STZ, the levels of FBG, FINS and HOMA-IR increased in all groups (all P<0. 05). After aerobics for 6w, the levels of FBG, FINS and HOMA-IR decreased in all aerobics groups compared with model group (allP<0. 05). The levels of FBG, FINS and HOMA-IR increased in high-intensity aerobics group compared with low-intensity aerobics group and mid-intensity aerobics group (allP<0. 05). After aerobics for 6w, the levels of MDA and NO and NOS activity decreased (P<0.01) and SOD activity increased (P<0.05) in all aerobics groups compared with model group, and levels of MDA and NO and NOS activity increased (P<0.05) and SOD activity decreased (P<0.05) in high-intensity aerobics group compared with low-intensity aerobics group and mid-intensity aerobics group. Conclusion The aerobics with low, mid or high intensity all can control the level of blood glucose, and reduce the levels of MDA, NO and NOS and promote SOD activity in diabetic rats, which plays a role in prevention of diabetic cardiomyopathy.
Keywords：Aerobicsdiabetic ratsBlood glucoseOxygen free radicals
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 356-358 )