Clinical application of thromboelastogram in antiplatelet treatment of coronary heart disease
ZHAO Shu-wu
WANG Yu-ping
XU Lin-dong
WEI Gang
Abstract：Objective To discuss the application value of thromboelastogram (TEG) in antiplatelet treatment in patients with coronary heart disease (CHD) and PCI. Methods The patients (n=90) were chosen and divided into stable angina pectoris group (SAP group), unstable angina pectoris group (UAP group) and acute myocardial infarction group (AMI group, each n=30). All patients were given detections of TEG and coagulation function test, and difference in TEG indexes, coagulation parameters and reactivity to antiplatelet treatment were compared among 3 groups. Results The levels of R, K, LY30, APTT, TT and INR decreased gradually, and levels of Angle, MA, CI, FIB and D-D increased gradually in all groups (all P<0.01-P<0.05). The high coagulation images of TEG were 0.0%, 33.3%and 50.0%respectively in SAP group, UAP group and AMI group. The incidence of high coagulation image was significantly higher in AMI group than that in SAP group and UAP group (P<0.05). The incidence of ischemia cardiac events increased significantly in patients with normal reactivity to antiplatelet treatment (9.2%) than that in those with lower reactivity to antiplatelet treatment (20.0%) within 3 m (χ2=4.347, P<0.05). Conclusion The detection of TEG can guide the administration of antiplatelet drugs and reduce the incidence of ischemia cardiac events.
Keywords：ThromboelastogramPercutaneous coronary interventionAntiplatelet therapy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 328-330 )