Correlation between asymptomatic hyperuricemia and number of carotid plaques

SONG Chang-zhao; DENG Ru-rong; CHENG Yao; XU Xian-lin; CHEN San-min; WANG Dao-wei

doi:10.3969/j.1674-4055.2014.03.26

Abstract：Objective To investigate the relationship between level of blood uric acid (BUA) and number of carotid plaques in patients with asymptomatic hyperuricemia. Methods The health persons (n=72) with physical examinations were chosen from the Huiyang Sanhe Hospital of Huizhou City of Guangdong Province from Jan. 2009 to Dec. 2013, and divided into high-BUA group (n=39) and normal-BUA group (n=33) according to their BUA level. The changes of BUA level were followed up for 5 years, and number of carotid plaques was detected. A correlation analysis on relationship between BUA level and number of carotid plaques was carried out. Results During 5-year follow-up period, BUA level was higher in the male than that in the female in 2 groups (P<0.05). BUA level was higher in the male and female in high-BUA group than that in the male and female in normal-BUA group (P<0.05). The changes of BUS level were not significant in the male and female in 2 groups during 5-year follow-up period, and there was no statistical difference in BUA level among different years (P>0.05). The number of carotid plaques was (1.9±0.5) averagely in the male and (1.2±0.3) in the female in high-BUA group, and (0.8±0.3) averagely in the male and (0.4±0.2) in the female in normal-BUA group (P<0.05). The number of carotid plaques was positively correlated to BUA level, and r=0.768 in the male and r=0.721 in the female (P<0.05). Conclusion The increase of BUA level is significantly correlated to the increase of number of carotid plaques.