Relationship between N-terminal pro brain natriuretic peptide or endothelin and heart function in patients with chronic heart failure
QIAN Wei-li
YANG Xin-chun
ZHANG Juan
LIU Ming-li
Abstract：Objective To investigate the relationship between N-terminal pro brain natriuretic peptide (NT-proBNP) or endothelin (ET) and heart function in the patients with chronic heart failure (CHF). Methods The CHF patients (n=56) were chosen as subjects and 20 volunteers with normal heart function were chosen as control group, and CHF patients were divided into grade II sub-group, grade III sub-group and grade IV sub-group according to NYHA grading. The levels of NT-proBNP and ET were detected respectively, changes of LVEF and LVDD were detected by using color Doppler echocardiography, and all outcomes were compared and analyzed among groups. Results The level of NT-proBNP was, respectively, (336.24±41.25) ng/mL, (1761.35±21.43) ng/mL, (2693.45± 41.54) ng/mL and (3161.26±67.56) ng/mL, and level of ET was, respectively, (19.89±11.35) ng/L, (48.60±21.25) ng/L, (61.56±31.68) ng/L and (161.67±46.56) ng/L in control group, grade II sub-group, grade III sub-group and grade IV sub-group. The levels of NT-proBNP and ET showed an ascending trend in control group, grade II sub-group, grade III sub-group and grade IV sub-group and difference had statistical significance (P<001). The comparisons in ET level and LVEF change had no statistical difference between grade II sub-group and grade III sub-group (P>0.05), and comparisons in levels of NT-proBNP and ET, and changes of LVEF and LVDD among other groups had statistical difference significantly (all P<0.01). The level of NT-proBNP was positively correlated to heart function grading (r=0.769, P<0.05), and was negatively correlated to LVDD (r=0.606, P<0.05) and LVEF (r=-0.656, P<0.05). The level of ET was positively correlated to heart function grading (r=0.357, P<0.05), and was negatively correlated to LVDD (r=0.265, P<0.05) and LVEF (r=-0.274, P<0.05). Conclusion The levels of NT-proBNP and ET will increase when CHF exacerbates, and they are correlated to heart function grading in the patients with CHF, which are significant to reviewing the severity and prognosis of CHF.
Keywords：Heart failureN-terminal pro brain natriuretic peptideEndothelin
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 311-313 )