Antithrombotic treatment for patients during perioperative period of non-cardiac surgery after intracoronary stent implantation
LI Jun-xia
WU Long-mei
GUO Je
TIAN Xin-li
SUN Qi
ZHANG Jian
WANG Shi-hong
SHI Yu-jie
YI Gui-yan
Abstract：Objective To discuss the antithrombotic therapeutic strategy for patients during perioperative period of non-cardiac surgery after drug-eluting stent implantation. Methods The patients (n=16) with drug-iluting stent implantation due to coronary heart disease and needed surgery because external diseases during the period of taking dual antiplatelet drugs were chosen from Jan. 2010 to Jun. 2013. Before the surgery for 3 to 5 d, dual antiplatelet drugs were substituted by tirofiban (0.1μg/kg·min) continuously, and 8 h before surgery, tirofiban was stopped. When there was no severe bleeding after the surgery, the dual antiplatelet treatment with tirofiban and aspirin was used again 24 h to 48 h after the surgery. The incidence of major adverse cardiovascular events (MACE) and bleeding events were observed during perioperative period and 3-month follow-up period. Results All 16 patients had no MACE and massive bleeding events, and only 2 had mild bleeding. Conclusion It is effective and safe that platelet receptor antagonists IIb/IIIa instead of dual antiplatelet drugs in the patients during perioperative period of non-cardiac surgery after drug-eluting stent implantation. Because of the cases are less in this study, more large-scale randomized controlled studies are required.
Keywords：Coronary heart diseaseStentStent thrombosisNon-cardiac surgeryreceptor antagonistsⅡb/Ⅲa
Publication Date：2014-01-01
Pages：3( 296-298 )