Curative effect of Roux-en-Y gastric bypass surgery in overweight patients with type 2 diabetes and its influence on cardiovascular risk

ZENG Sha-sha; HUANG Ji; SHE Qiang; LIAO Yong; GUO Yu-ming

doi:10.3969/j.1674-4055.2014.03.15

Abstract：Objective To review the curative effect of Roux-en-Y gastric bypass (RYGB) surgery in overweight patients with type 2 diabetes and its influence on cardiovascular risk. Methods There were totally 57 patients having RYGB surgery in the Hospital of Chinese PLA Chongqing General Unit from Mar. 2011 to Mar. 2012. The changes of fasting plasma glucose (FPG), 2-h postprandial blood glucose (2hPG), HbA1c, BMI, blood pressure (BP) and blood fat were detected before the surgery and 6 m after the surgery. All patients were divided into hypertension group (n=30) and normal group (n=27). The cardiovascular risks were reviewed by using Chinese risk assessment model of ischemia cardiovascular diseases (ICVD) and Framingham risk assessment model before and after the surgery. Results After the surgery for 6 m, FPG, 2hPG, HbA1c, BMI, systolic BP and diastolic BP all decreased significantly than those before the surgery (all P<0.01). The levels of TG, TC and LDL-C decreased after the surgery (all P<0.05), and levels of HDL-C and ApoA1/ApoB had no significant changes (P>0.05). In 30 patients with complicating primary hypertension, systolic BP and diastolic BP decreased significantly after the surgery (all P<0.01). In the patients with grade 3 hypertension, the descend range of BP increased compared with those with grade 1 or grade 2 hypertension (all P<0.05). The assessment 6 m after the surgery showed that the cardiovascular risk decreased significantly in the next decade. There were no deaths or severe adverse reactions observed. Conclusion RYGB surgery can ameliorate blood glucose, BP and blood fat, and reduce the cardiovascular risk in the next decade in overweight patients with type 2 diabetes.