Thrombelastography for reviewing antiplatelet efficacy of ticagrelor and clopidogrel in patients with acute coronary syndrome
WANG Li-li
LI Qun
KANG Lin
LI Xin
GUO Xiao-ning
ZHANG Tao
Abstract：Objective To observe the antiplatelet efficacy of ticagrelor or clopidogrel in the patients with acute coronary syndrome (ACS) treated with dual antiplatelet drug by using thrombelastography (TEG) for detecting platelet aggregation rate. Methods The patients with ACS (n=84) were randomly divided into clopidogrel group and ticagrelor group (each n=42). The platelet aggregation rate was compared by using TEG between 2 groups after treatment with ticagrelor or clopidogrel. Results There were 11 patients (26.19%) had clopidogrel resistance in clopidogrel group, and 1 patient (2.38%) had ticagrelor resistance in ticagrelor group (χ2=9.722, P=0.002). There was 1 patients (2.38%) had aspirin resistance in clopidogrel group, and 2 patients (4.76%) had aspirin resistance in ticagrelor group (χ2=0.346,P=0.557). Conclusion Some ACS patients treated with standard antiplatelet therapy have antiplatelet resistance, and TEG outcomes show that the antagonizing effect of ticagrelor on platelet aggregation is better than that of clopidogrel.
Keywords：ThrombelastographyAcute coronary syndromeClopidogrelTicagrelorDrug resistance
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 281-284 )