Influences of Qili Qiangxin Capsules on heart function and expression of high mobility group box 1 protein (HMGB1) in patients with dilated cardiomyopathy
WU Hui
YANG Jun
DING Jia-wang
Li Song
YANG Jian
DONG Wu-song
TONG Xiao-hong
LI Xiu-juan
LI Li
LV Zhi-yang
ZHANG Jiong
Abstract：Objective To observe the influences of Qili Qiangxin Capsules on heart function and expression of high mobility group box 1 protein (HMGB1) in the patients with dilated cardiomyopathy (DCM). Methods The patients (n=48) with grade II DCM and grade III DCM (NYHAgrading) were chosen from Jan. 2012 to Aug. 2013, and then divided randomly into observation group and control group (each n=24). Both groups were given standardized therapy of Western drugs and observation group was additionally given Qili Qiangxin Capsules (0.3 g/capsule) 4 capsules once and 3 times a day for 12 w. The changes of 6-minute walk test (6MWT) and LVEF were detected in 2 groups before and after treatment. The expressions of serum HMGB1, IL-6 and TNF-αwere detected by using ELISA. Results 6MWT and LVEF were increased significantly (P<0.01), and expressions of serum HMGB1, IL-6 and TNF-αdecreased significantly (P<0.01) in 2 groups after treatment. 6MWT was (365 ±59) m and LVEF was (39.3±8.8)%in control group, and 6MWT was [(389±63) m] and LVEF was [(44.6± 9.3)%] in observation group after treatment (P<0.05). The expressions of serum HMGB1, IL-6 and TNF-αwere, respectively, (13.37±3.86) pg/ml, (89.1±18.5) ng/ml and (18.3±4.2) ng/ml in control group, and[(9.61±3.25) pg/ml], [(65.9±12.4) ng/ml] and [(13.6±3.5) ng/ml] in observation group after treatment (P<0.05). Conclusion Qili Qiangxin Capsules can further improve heart function and reduce the expressions of HMGB1, IL-6 and TNF-αduring treatment in the patients with DCM.
Keywords：Qili Qiangxin CapsulesDilated cardiomyopathyHeart functionHigh mobility group box 1 protein
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 271-273 )