Influences of abnormal circadian rhythm of blood pressure on carotid artery intima-media thickness and left ventricular hypertrophy
WANG Ji
YIN Shuang-yan
QIN Ai-mei
WANG Hao
ZHU Bing
SUN Yu-qing
ZHAO Xiao-qian
SUN Hong-liang
HU Zhi
DU Kai-yin
LUO Lei-ming
Abstract：Objective To investigate the influences of abnormal circadian rhythm of blood pressure (BP) on carotid artery intima-media thickness (CA-IMT) and left ventricular hypertrophy (LVH) in the elderly patients with primary hypertension. Methods The elderly patients (n=280) were chosen and their data were collected by using 24-h ambulatory blood pressure monitoring (ABPM), carotid ultrasound and echocardiography. All patients were divided, according to circadian rhythm of BP and percentage of systolic BP (ΔSBP%), into dipper group (n=125,ΔSBP%≥10%but<20%), non-dipper group (n=92,ΔSBP%≥0%but<10%), reverse-dipper group (n=41,ΔSBP%<0%) and extreme-dipper group (n=22,ΔSBP%≥20%). The incidence rates of bilateral CA-IMT thickening and LVH were compared and analyzed in 4 groups. Results The incidence rate of CA-IMT thickening was 44.0%in dipper group, 58.7%in non-dipper group, 77.3%in extreme-dipper group and 80.5%in reverse-dipper group (P<0.01). The incidence rate of LVH was 30.4%in dipper group, 44.6%in non-dipper group, 50.0%in extreme-dipper group and 61.0%in reverse-dipper group (P<0.01). The incidence rate of CA-IMT thickening complicating LVH was 20.8%in dipper group, 34.8%in non-dipper group, 40.9%in extreme-dipper group and 48.8% in reverse-dipper group (P<0.01). The multifactor logistic regression analysis showed that low-density lipoprotein-cholesterol (LDL-C) and fasting plasma glucose had independent predictive effects to the morphological features of BP circadian rhythm (P<0.05). Conclusion The incidence rates of CA-IMT thickening and LVH will significantly increase as the severity of abnormal BP circadian rhythm exacerbates in the elderly patients with hypertension.
Keywords：ElderlyHypertensionRhythm of blood pressureAtherosclerosisLeft ventricular hypertrophy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 267-270 )