Cohort study on relationship between patent foramen ovale and ischemia stroke:a Meta-analysis
MA Bing
CHEN Xin
SUN Hao
ZHANG Jian-ming
Liu Yi-ting
SHI Jing-pu
Abstract：Objective To study systematically the relationship between patent foramen ovale (PFO) and ischemia stroke. Methods The databases of CNKI, CBM disc, PubMed, Embase and Google Scholar were retrieved to choose cohort studies on the relationship between PFO and ischemia stroke. The relationship was analyzed through Meta-analysis by using Stata11.0 software. Results There were totally 6 cohort studies retrieved out. The Meta-analysis showed that the risk of stroke had no significant changes in the patients without PFO (HR=1.27, 95%CI:0.98-1.64, P=0.074) compared with those with PFO. In the patients with PFO, the risk of complicating atrial septal aneurysm (ASA) increased (HR=2.58, 95%CI:1.03-6.49, P=0.043). The outcomes of transesophageal echocardiography showed that the risk of stroke was 1.45 times in patients with PFO more than that in patients without PFO (HR=1.45, 95%CI:1.06-2.01, P=0.024). Conclusion PFO is not an independent risk factor of stroke, but will increase the risk of stroke when PFO complicating ASA. It needs more large-sample cohort studies to confirm the conclusion.
Keywords：Patent foramen ovaleIschemia strokeCohort studyMeta-analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 255-258 )