A Meta-analysis on curative effect of atorvastatin on atherosclerosis
TANG Shao-wen
SHI Min-hong
XU Zhen-lin
CHEN Ru
WANG Jing
XU Biao
Abstract：Objective To review systematically the curative effect of atorvastatin on atherosclerosis in patients with atherosclerosis treated with atorvastatin besides of routine treatment in China. Methods The databases of PubMed, EMBASE, CENTRAL, CBMDisc, CMCI, CNKI, VIP and WanFang were retrieved with computer for collecting the randomized or semi-randomized clinical trials about the curative effect of atorvastatin on atherosclerosis, and then 2 reviewers independently reviewed trial quality, extract material and checked data. The software of Review manager 5.2.1 was used for analyzing mean difference (MD) and 95%confidence interval (CI). Results There were totally 27 trials included involving 1558 cases in intervention group and 1495 cases in control group. The Meta-analysis showed that carotid artery intima-media thickness (CA-IMT) was reduced by 0.15 mm (95%CI:-0.30--0.01) after treatment with atorvastatin (10 mg/d) for 24 w, and by 0.81 mm (95%CI:-1.11--0.51) after 96 w in intervention group compared with control group. CA-IMT was reduced by 0.10 mm (95%CI:-0.18--0.03) after treatment with atorvastatin (20 mg/d) for 12 w, by 0.36 mm (95%CI:-0.49--0.23) after 24 w, and by 0.22 mm (95%CI:-0.31--0.13) after 48 w in intervention group compared with control group. Conclusion Atorvastatin can effectively reduce CA-IMT and delay the development of atherosclerosis.
Keywords：AtorvastatinAtherosclerosisMeta-analysisCarotid artery intima-media thickness
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 248-251 )