Influences of ischemic postconditioning on reperfusion arrhythmia and myocardial damage in patients with ;acute myocardial infarction
WANG Yin-hua
WANG Bao-hua
BAI Jing
TANG Ming-gui
CAI Hai-xia
WANG Jian-jun
PU Jian-yi
Abstract：Objective To investigate the influences of ischemic postconditioning (IPC) on reperfusion arrhythmia and myocardial damage in patients with acute myocardial infarction (AMI) during direct percutaneous coronary intervention (PCI). Methods The patients with first AMI treated with direct PCI (n=110) were randomly divided into routine PCI group (n=52) and IPC group (n=58). All patients were given CAG via right femoral artery, and PCI to infarction-related artery (IRA). The arrhythmia were recorded during PCI and after PCI for 2 h. The conventional 18-lead ECG was recorded at the same time every day until 1 w after PCI. The corrected QT dispersion (QTcd) was calculated, changes of CK-MB were monitored 1 w after PCI and incidence of MACE was observed during hospitalization. Results The incidence rates of bradyarrhythmia and tachyarrhythmia were 10.7%and 23.2%in IPC group during PCI and 2 h after PCI, and 30.0%and 54.0%in routine PCI group. The incidence of reperfusion arrhythmia was 33.9%in IPC group and 84.0%in routine PCI group (P<0.05). The comparison in the incidence of MACE showed no statistical significance between 2 groups (P>0.05). QTcd was (62.18±4.25) ms in routine PCI group and (63.66±3.19) ms in IPC group before PCI, and decreased 1 w after PCI [(56.89±4.67) ms in routine PCI group and (47.31±4.43) ms in IPC group], and the decrease was more significant in IPC group (P<0.05). The peak value of CK-MB was (121±52) U/L in IPC group and (166±47) U/L in routine PCI group (P<0.05). Conclusion IPC can reduce the incidence rate of reperfusion arrhythmia, decrease QTcd and relieve myocardial damage in AMI patients after PCI.
Keywords：Acute myocardial infarctionReperfusion arrhythmiaIschemic postconditioningPercutaneous coronary intervention
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 153-155,159 )