Value of ischemia modified albumin to curative effect reviewing in treatment of acute ST-segment ;elevation myocardial infarction and reperfusion
CHEN Yun-xian
TANG Liang-qiu
XU Xin
MA Shao-chun
ZHANG She-bing
HE Feng-ping
CHEN Bao-feng
CHEN Jin-feng
Abstract：Objective To discuss the early changes and value of ischemia modified albumin (IMA) to curative effect reviewing in treatment of myocardial ischemia and reperfusion in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods The STEMI patients (n=160) treated with acute PCI were chosen and divided into completed group (ST-segment resolution≥70%, n=92) and incompleted group (ST-segment resolution<70%, n=68) according to ST-segment resolution on ECG 90 min after PCI. The level of serum IMA was detected in two groups before and after PCI, and variation of IMA (δIMA) were calculated. The peak value of cTnI before and after PCI for 4 h, 8 h, 12 h and 24 h, and serum hs-CRP level on the 2nd d after PCI were detected. The correlation betweenδIMA and ST-segment resolution degree was verified by using Pearson correlation test. The predictive value ofδIMA to ST-segment resolution degree was reviewed with area under ROC curve. Results The level of serum IMA increased significantly (P<0.01) and cTnI peak value and hs-CRP level increased significantly (P<0.05) in completed group compared with incompleted group (r=0.525, P<0.01). When takingδIMA=19.505 U/ml as cutoff point, the positive predictive value to complete ST-segment resolution was 77.2%and negative predictive value was 69.1%. The area under ROC curve was 0.794 (95%CI:0.723-0.865, P<0.01). Conclusion The early changes of serum IMA can predict ST-segment resolution degree in the patients with STEMI treated with PCI, which can be taken as an early sensitive index for reviewing curative effect on myocardial ischemia and reperfusion.
Keywords：Ischemia modified albuminAcute myocardial infarctionMyocardial reperfusion injuryPercutaneous coronary intervention
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 146-148,152 )