Curative effect and safety of nicorandil in treatment of unstable angina pectoris:a Meta-analysis
ZHAO Ming-ming
WANG Hai-rong
XIONG Feng
NIE Chen
ZHOU You
Abstract：Objective To review systematically the curative effect and safety of nicorandil in treatment of unstable angina pectoris (UAP). Methods The databases of Cochrane Controlled Trials Register, PubMed, EMbase, WanFang Database, VIP Database, CNKI and CBM were retrieved with computer for collecting clinical randomized controlled trials (RCT) about treatment of UAP with nicorandil. According to inclusion and exclusion criteria, 3 researchers screened RCT, extracted data and review the quality of methodology independently. After cross checking, RevMan5.1 software was used for a Meta-analysis. Results There were totally 12 RCT included involving 1002 patients, and the results of Meta-analysis showed that nicorandil was better than nitrates in the aspect of curative effect on UAP (RR=1.23, 95%CI:1.13-1.35) and in the aspect of improving ECG (RR=1.74, 95%CI:1.43-2.12), and had no statistical significance in the aspect of incidence of adverse reactions (RR=0.71, 95%CI:0.50-1.02). Conclusion Nicorandil is similar to nitrates in the aspect of curative effect on UAP with lower incidence of adverse reactions. As the study included less samples, methodological quality was lower and therapeutic courses were not the same, the conclusion should be cautiously accepted.
Keywords：NicorandilNitroglycerinIsosorbide mononitrateIsosorbide dinitrateUnstable angina pectorisMeta-analysis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 131-135 )