Renin-angiotensin-aldosterone system and prognosis of acute myocardial infarction
XIONG Li
LUO Bin-hua
WANG Nan-li
WANG Xiao-hua
Abstract：Objective To study the correlation between renin-angiotensin-aldosterone system (RAAS) and short-term prognosis of acute myocardial infarction (AMI). Methods The patients (n=33, AMI group) and health persons (n=30, control group) were chosen from the People’s Hospital of Jiangxi Province from Jun. 2012 to Dec. 2012. The levels of plasma rennin activity (PRA), angiotensinⅡ(AngⅡ) and aldosterone (Ald) were compared between two groups. After 3 months, the left ventricular function (including LVEDD, LEVSD and LVEF) was detected by using color Doppler and the correlation between these indexes and RAAS was observed. AMI group was further divided into low AngⅡgroup (AngⅡ≤249.1 pg/mL, n=19) and high AngⅡgroup (AngⅡ>249.1 pg/mL, n=14) and the incidence of major adverse cardiovascular events (MACE) was observed during 3-month follow-up period. Results Compared with control group, the levels of PRA [(6.5±2.4) ng/(mL.h) vs. (0.5±0.4) ng/(mL.h)], AngⅡ[(226.9±66.3) pg/mL vs. (47.4±11.9) pg/mL] and Ald [(401.8±91.2) vs. (294.1±43.4) pg/mL] were higher in AMI group (P<0.01). The level of AngⅡwas positively correlated to levels of LVEDD (r=0.788, P<0.01) and LEVSD (r=0.770, P<0.01), and negatively correlated to level of LVEF (r=-0.782, P<0.01) in two AngⅡgroups. The incidence of MACE was significantly higher in high AngⅡgroup than that in low AngⅡgroup (100%vs. 42.11%, P<0.01) within 3 months. Conclusion An excessive activation of RAAS can be observed in AMI patients, and level of AngⅡis positively correlated to left ventricular remodeling, heart function and MACE after AMI.
Keywords：Renin-angiotensin-aldosterone systemAcute myocardial infarctionShort-term prognosis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 92-94 )