Relationship between level of plasma MMP-1 and left ventricular outflow tract obstruction in patients with hypertrophic cardiomyopathy
ZHAN Jiang
ZHANG Chun
Abstract：Objective To discuss the relationship between level of plasma matrix metalloproteinase-1 (MMP-1) and left ventricular outflow tract obstruction in patients with hypertrophic cardiomyopathy (HCM). Methods HCM patients (n=72) were divided into high MMP-1 group (n=34) and low MMP-1 group (n=38) taken average level of MMP-1 (5.13 ng/mL) as a bound. The difference in indexes of sex, age and ultrasound image, and correlation between these indexes and MMP-1 were analyzed. The level of MMP-1 was compared between the patients with obstructive HCM and those with non-obstructive HCM. Results The comparison between low MMP-1 group and high MMP-1 group showed that there were statistical differences in age, NT-proBNP, LVOTPG, LVEF and LVPWD (P<0.05). NT-proBNP was positively correlated to MMP-1 (r=0.521, P=0.025), LVOTPG was positively correlated to MMP-1 (r=0.596, P=0.018), LVEF was negatively correlated to MMP-1 (r=-0.471, P=0.031), and LVPWD was not correlated to MMP-1. The relation between age and MMP-1 showed a nonlinear correlation. The level of MMP-1 increased significantly in the patients with obstructive HCM compared with those with non-obstructive HCM (P<0.05). Conclusion MMP-1 is correlated to NT-proBNP, LVOTPG and LVEF, which is valued to the diagnosis of left ventricular outflow tract obstruction in HCM patients.
Keywords：Matrix metalloproteinase-1Hypertrophic cardiomyopathyOutflow tract obstruction
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 68-70 )