Characteristics of coronary lesion in patients with coronary heart disease combined with nonalcoholic fatty liver
ZHANG Jing
HE Sheng-hu
WANG Xue-fei
Abstract：Objective To discuss the incidence of nonalcoholic fatty liver (NAFLD), characteristics of coronary lesion and possible mechanism in patients with coronary heart disease (CHD). Methods The patients (n=158) with CHD diagnosed by CAG were chosen as CHD group from the Subei People’s Hospital from Jun. 2011 to Dec. 2012. Other 142 patients with negative CAG results were chosen as control group. The incidence of NAFLD was compared according to color Doppler ultrasound and drinking status between two groups. CHD group was further divided into NAFLD sub-group (n=158) and non-NAFLD sub-group (n=142). The number of lesion vessels and degree of vascular stenosis were observed and compared between two sub-groups. The levels of nitric oxide (NO) and endothelin (ET) were detected and compared respectively by using radioimmunoassay and nitrate reductase method in two sub-groups. Results The incidence of NAFLD was significantly higher in CHD group than that in control group (58.2%vs. 36.6%). The percentages of multiple coronary vessel lesion (41.8%vs. 31.1%), severe stenosis (24.7%vs. 10.6%) and complete occlusion (19.0%vs. 6.3%) were significantly higher in NAFLD sub-group than those in non-NAFLD sub-group (P<0.05). The level of NO decreased significantly and level of ET increased significantly (P<0.05) in NAFLD sub-group compared with non-NAFLD sub-group. Conclusion Nonalcoholic fatty liver has predictive value to diagnosis and severity of CHD, and the mechanism may be related to endothelial function effected by NAFLD.
Keywords：Coronary heart diseaseCoronary lesionNonalcoholic fatty liverEndothelial function
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 65-67 )